TRONNAL
BIOMEDICINE
创 元 生 物
Technical achievements
A CDMO company serving global innovative drug companies with top-notch chemical total synthesis technology
Paclitaxel and Its Artificial Total Synthesis
· R&D and industrialization of artificial total synthesis and related anticancer drugs
· In 2019, only the preparation market in China will exceed RMB 21 billion, and the
global market will exceed RMB 100 billion
Wide range of applications
The first chemical drug from natural plants approved by the FDA in the United States is considered to be one of the most effective anti-cancer agents in the next 20 years. CELEGENE's Abraxane® has created a At least more than 5 billion US dollars in global sales.
Harsh synthesis conditions
The current optimal results have too many synthesis steps (at least 37 steps), the overall yield of synthesis is extremely low, and the highest yield does not exceed 2%
At present, the synthesis conditions of the results are harsh, and the cost of reagents is high, which is not meaningful for industrial production.
Very low natural content
Very low natural content in plants (up to only 0.069%) About 13.6kg of bark can produce 1g of paclitaxel.
important meaning
More than 40 first-class research teams around the world are engaged in the total synthesis of paclitaxel, and only 6 teams have publicly reported the completion of the total synthesis route.
It is of great significance to find new ways to obtain paclitaxel and realize mass production.
This project has made positive progress in the artificial total synthesis of paclitaxel, and is expected to achieve practical results soon.
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