TRONNAL
BIOMEDICINE
创 元 生 物
Technical achievements
A CDMO company serving global innovative drug companies with top-notch chemical total synthesis technology
Cyclocitrinol
The first total synthesis
This compound has nerve cell repairing activity
★ synthetic competition： Leighton (Columbia University, 15 years), Schmalz, Rigby, Ding, Gui, Li(2000-2018: 6 papers and 8 PhD thesis)
The equivalent of 32 years of work for a doctoral student!
First total synthesis：
Our team
J.Am.Chem.Soc.
2018,140,5365.
Type II
[5+2]
Synthetic challenges:
Bicyclo [4.4.1] A/B ring system
Strained bridgehead (anti-Bredt) double bond
8 stereocenters:two quaternary
This word: First total synthesis in 18 stes: Type II [5+2]
cyclocitrinol:
bicyclo[4.4.1]rings
strained anti-Bredt olefin
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