TRONNAL
BIOMEDICINE
创 元 生 物
Technical achievements
A CDMO company serving global innovative drug companies with top-notch chemical total synthesis technology
Vinigrol
Efficient total synthesis
One of the most difficult molecules in the history of natural product synthesis:
High tension bridge ring system, 8-membered ring
8 consecutive chiral centers, 1 quaternary carbon
Racemic Total Synthesis: Baran (the most talented young organic chemist, 23 steps);
Njardarson (43 step)
Asymmetric total synthesis:
Our team，J. Am. Chem. Soc. 2019, ASAP.
（Type II [5+2]，14 step，After 6 years）
>20 team studies: Corey (Nobel Laureate);
Paquette; Barriault; et al.
(1987-2008, >20 papers and 10 PhD theses)
bicyclo[5.3.1]undecane
(Paclitaxel-like structure)
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